Medicinal Chemistry

Introduction The revolution of medicinal chemistry had occurred recently. A much better understanding of how the body works- including every organ in the body- at a cellular and the molecular level occurred as a result of the rapid advance in the biological sciences. In any drug design, there are two major considerations that must be … Read more

Can E. arvense extract work against CPA?

Abstract In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the CA and MI in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with … Read more

Personalised medicine for cancer

Introduction Mutations that are occured at oncogenes and tumor suppressor genes causes genomic alteration. These genomic alterations play a key roles to occur formation, progressing and metastasis of cancer. To understand developing and progressing of cancer mechanism and also enhancing personalized cancer treatments are both associated with analyzing and distinguishing of all genomic alteration in … Read more

The role of the dioxegenase Jumonji C domain-containing Protein 6 in Vaccinia virus reproduction

Introduction. Jumonji C domain-containing protein 6 (Jmjd6) belongs to a superfamily of oxygenases which rely on the presence of non-haem iron (Fe(II)) and 2-oxogluatarate for their function. The Jmjd6 gene was initially believed to be involved in engulfment of apoptotic cells as it was initially thought to encode a phosphatidylserine receptor however this is now … Read more

Microbiota in viral infections: an immunity booster or buster?

Abstract: Microbiota is basically an ecological community comprised of commensal, pathogenic and symbiotic microorganisms providing protection against incoming bacterial pathogens. They play a dominant role in modulation of host health by contributing to immunologic, hormonal and metabolic homeostasis. The immune system-microbiota interactions have a symbiotic relationship where microbiota plays an important role in the induction, … Read more

The application of genetic engineering to medicine

CHAPTER 1 INTRODUCTION 1.1 WHAT IS GENETIC ENGINEERING? Genetic engineering or genetic modification is the alteration or modification of an organism’s genome using modern DNA technology (Biotechnology). It usually involves the introduction of foreign DNA or synthetic genes into the organism; the new resulting organism is often referred to as transgenic and or genetically modified … Read more

Effect of maslinic acid on the immune function of liver (Research Proposal)

Introduction Maslinic acid, also known as crategolic acid or (2α, 3β)-2, 3-dihydroxyolean-12-en-28-oic acid is a pentacyclic triterpene widely spread in the plant kingdom. We examine the potential of one group of compounds called triterpenes, derived from traditional medicine and diet for their ability to suppress inflammatory pathways. In the last decades, and in response to … Read more

Oral leukoplakia (OL)

Introduction Oral leukoplakia (OL) is the most common potentially malignant disorder of the oral mucosa. [1] Leukoplakia may occur anywhere on the oral mucosa and its prevalence varies from 0.2% to 5.2% of the Indian population. [2] The tobacco chewing habit both in smoking and smokeless form is the most common cause for oral leukoplakia. … Read more

The effect of charge on polymersomal drug delivery systems

1.0 Introduction In recent years, new APIs have increasingly reduced in solubility and is estimated that approximately 70% of new chemical products possess low solubility in both aqueous and organic environments.1 This has led to one of the main confronts of the pharmaceutical industry, proving that effective drug delivery systems are as essential as pharmacodynamics … Read more