Blood pressure is the force at which blood pushes against the walls of your arteries. (Coventry lecture notes) Blood needs to be under a certain amount of pressure in the arteries to get the blood around the body (British Heart Foundation 2010). High blood pressure known as hypertension puts strain on the heart and blood vessels which can then increase the risk of heart attacks, strokes, kidney failure and eye damage (BDA 2016). Blood pressure is monitored in the body by control centres in the cardiovascular centre found in the medulla oblongata of the brain and the adrenal medulla which is next to the kidney.
Neuronal Mechanisms in the control of blood pressure:
Baroreceptors are sensory receptors which detect changes in pressure and stretch in the walls of arteries. They then send signals to the cardiovascular centre to reverse the change. Baroreceptors are found in large arteries in the neck and chest such as the aorta and internal carotid arteries. High blood pressure results in the carotid sinus (in the artery wall) being stretched more because the blood is pushing against the artery walls, this stimulates the baroreceptors which quickly send impulses to the medulla oblongata in the brain (Tortora and Derrickson 2009). The medulla oblongata increases parasympathetic activity to the sinoatrial node of the heart and decreases sympathetic activity. The parasympathetic nervous system works by increasing the diameter of the arteries, slowing the heart rate and decreasing the amount of blood pumped by the heart per heart beat (stroke volume), this results in a lowered blood pressure (Coventry lecture notes)
Chemoreceptors are sensory receptors which detect changes in the amount of chemicals in the blood, for example carbon dioxide, oxygen and hydrogen ion concentrations. They are found near the baroreceptors in the arch of the aorta in structures called carotid and aortic bodies. Changes in the concentrations of chemicals in the blood stimulates the chemoreceptors to send signals to the medulla oblongata in the brain. This leads to an increase in activity in the sympathetic nervous system which narrows the blood vessels (vasoconstriction) and increases the heart rate, stroke volume and blood pressure (Tortora and Derrickson 2009).
Hormonal Mechanisms in the control of blood pressure:
Renin-angiotensin-aldosterone (RAA) system: Juxta-glomerular cells in the kidney secrete renin, which is an enzyme that hydrolyses (breaks down using water) angiotensinogen into angiotensin I. Angiotensin-converting enzyme (ACE) changes angiotensin I into angiotensin II (Tortora and Derrickson 2009). Angiotensin and angiotensin II are substances that cause the blood vessels to become narrower (vasoconstriction) and therefore increases blood pressure as the blood is travelling in a smaller space (Edward D and Frohlich MD 1983). Angiotensin II levels increase 2-3 times in obese patients (Guyton and Hall). This explains why people who are obese tend to have high blood pressure because they have more angiotensin II which narrows the blood vessels causing the blood to be under a higher pressure. Angiotensin II also causes aldosterone to be released into the blood which is a hormone that regulates …
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