Is Laser Doppler Imaging of additional value compared to the golden standard in the diagnosis of small-fiber neuropathy?

  1. ABSTRACT INTRODUCTION Small-fiber neuropathy (SFN), a disease known for its dysfunction of thin myelinated A??-fibers and unmyelinated C-fibers, is clinically characterized by sensory and autonomic symptoms. To date, the diagnosis of SFN is set by an abnormal intraepidermal nerve fiber density (IENFD) by skin biopsies and/or an abnormal quantitative sensory testing (QST) in … Read more

Safety signals

A safety signal is information on a new or known adverse event that is potentially caused by a medicine and that requires further investigation. 2 Signals can be obtained from a number of sources such as spontaneous reports, non clinical data, interventional and non-interventional studies, systematic reviews and meta-analyses, clinical studies, quality data and scientific … Read more

The LDIflare method

The LDIflare method is of additional value compared to the golden standard however rather in a screening program than in a diagnostic process of small-fiber neuropathy because of too low sensitivity. A limitation of this method is that it cannot differentiate between painful and non-painful small-fiber neuropathy. By using the non-invasive and objective LDIflare method … Read more

Electrocardiogram (ECG) review

1. Electrocardiogram The electrocardiogram (ECG) is a time-varying signal reflecting the ionic current flow which causes the cardiac fibers to contract and subsequently relax. The surface ECG is obtained by recording the potential difference between two electrodes placed on the surface of the skin [1]. Dr. Willem Einthoven invented the first ‘electrokardiogram’ in 1902; the … Read more

Malaria

2.0 Literature review 2.1 Malaria an Overview Malaria is caused by species of parasites of the genus Plasmodium that affect humans (P. falciparum, P. vivax, P. ovale, and P. malariae). Malaria caused by P. falciparum is the most deadly form. It predominates in Africa; P. vivax is less dangerous but more widespread, and the other … Read more

An Evaluation of Cost Related to Individuals Awaiting Case Management

Mental health over the past few years has risen to the forefront of issues to pay attention to in Canada, specifically since the major shift from deinstitutionalization in the 60’s (Davis, 2006). The locus of treatment has shifted away from a strict medical model to one that is emphasized in human dignity, recovery, and prevention; … Read more

Speech Disorder – Vocal Folds

Vocal Pathologies arise due to accident, disease, misuse of the voice, or surgery affecting the vocal folds and have a profound impact on patients’ life. The modeling of normal and pathological voice source and the analysis of healthy and pathological voices has gained increasing interest recently. Among the most interesting works are those concerned with … Read more

Non-drug modalities as an alternative to reduce side effects in pain management

LIST OF ABBREVIATIONS: PENS- Percutaneous Electrical Nerve Stimulation TENS-Transcutaneous Electrical Nerve Stimulation NSAIDs- Non-steroidal Anti-inflammatory Drugs SNRIs- Selective Norepinephrine Reuptake Inhibitors BACKGROUND Why did I take this up for detailed study? Pain remains as one of the most common reasons for visits to a doctor. Although all doctors are familiar with pain as a complaint, … Read more

Health promotion and chronic kidney disease

What is health? According to the World Health Organization (WHO), health is ‘a resource for everyday life, not the objective of living. Health is a positive concept emphasizing social and personal resources as well as physical capacities’ (WHO). Decades ago governmental officials of the world, agreed to come together, despite of whatever conflicts, or political … Read more

Mycobacterial infections

Abstract: Mycobacterial infections are infectious diseases. Control of TB is complicated by difficulties in the long-course chemotherapy treatment, the inability to eliminate latent microbes, and the increasing emergence of multidrug resistant strains of M. tuberculosis. New anti-TB drugs are urgently needed, including developments of short-term treatments to minimize the emergence of drug resistance and new … Read more

Patient assessment

Rosa Lee is a 52 year old African American female who is of below average height and slightly overweight. Rosa has given birth to a total of eight children who were fathered by six different men. Rosa has a thirteen year history of substance abuse. The substances that she has a history of using include … Read more

Dental erosion

Introduction Dental erosion is the process in which the rapid, inevitable dental tissue loss tissues occurs derived by a chemical process without involvement any bacteria and is a greater clinical challenge. Acids which cause the erosion are from dietary, occupational or intrinsic sources. Clinical problems associated with the dental erosion are dentine hypersentivity ,altered occlusion … Read more

Models of disability

2.3. The Social and Medical Model of Disability-Affirmative, Environmental, Attitudinal This is the two pragmatic models of disability, though there is the psychological and the most recent one, the administrative or charity model. Some expert has argued that disability is a personal tragedy or part of life caused by societal barriers, while other overview it … Read more

Implementing changes in healthcare systems and environments

Changes in various sectors of the healthcare system are constantly taking place. It continues to be a driving force in the quest so as to balance cost containment and improved healthcare quality (Omachonu et al, 2010). Various strategies are implemented to combat hospital acquired infections and there is a high priority to increase compliance rate … Read more

Cephalometry

Cephalometry has been an important tool in orthodontic diagnosis, treatment planning, and evaluation of treatment need and results 1-3; from the time of its introduction by Hofrath4 and Broadbent5 in 1931; and its popularisation by Steiner 6, 7. The conventional cephalometric diagnosis is based on the standardised norms; the population mean and range for separate … Read more