Understanding the role of G protein-coupled receptors in chemokine signaling and breast cancer metastasis
G protein coupled receptors (GPCRs) are cell surface receptors and members of the seven-transmembrane superfamily that initiates intracellular signaling primarily via the activation of heterotrimeric G proteins (alpha, beta, and gamma). GPCRs are activated by several ligands including neurotransmitters, chemokines, hormones, calcium ions (Ca2 +), and sensory stimuli. The processes of GPCR signaling system … Read more