Inborn error of metabolism (IEM)
The term “inborn error of metabolism (IEM)” was firstly presented by Sir Archibald E. Garrod, in the 1908 during his studies on alkaptonuria (1). Since then, the number of diseases caused by IEM has increased, due to new identification techniques for the various biochemical phenotypes, and, since then, more than five hundred different IEM have … Read more