p53 tumor supression

Abstract p53 as a tumor suppressor, assumes a crucial part in tumor suppression. The most generally mutated gene in cancer is TP53. As a transcription factor, p53 for the most part applies its part in tumor suppression through transcriptional control of its downstream target genes. Therefore, p53 and its objective genes structure a complex p53 … Read more

Has the cost of R & D impacted vaccine development for Covid-19?

Introduction This report will be investigating and trying to answer the question of: ‘To what extent have the cost requirements of R&D, structure of the industry and government subsidy affected firms in the pharmaceutical industry in developing vaccines for Covid-19?’. The past two years have been very unpredictable for the pharmaceutical industry regarding the breakout … Read more

Lyrica (pregabalin)

Background/Introduction Lyrica also known as pregabalin is an anti-epileptic drug also known as an anticonvulsant. It is also used to treat nerve pain and fibromyalgia (1). Epilepsy is a neurological disorder characterized by having recurrent seizures (2). Epilepsy can be treated with a select group of drugs; one other treatment is neurotonin (gabapentin) which is … Read more

Fracture union

Management of trauma has always been one of the surgical subsets in which oral and maxillofacial surgeons over the years. The mandibular body is a parabola-shaped curved bone composed of external and internal cortical layers surrounding a central core of cancellous bone. The goals of treatment, are to restore proper function by ensuring union of … Read more

Influence of Elicitors on major Withanolide Content in Withania somnifera

REVIEW OF LITERATURE Ever since ancient times, people looked for drugs in nature for rescue for their disease (Petrovska, 2012). Medicinal plant species constitute important alternatives to conventional medicine in a large number of developing countries. Gonzalez et al. (2013) reported that native medicinal plants of both the palaeotropics and neotropics have traditionally had a … Read more

CRISPR/Cas9 overview – application, mechanism, advantages & limitations

Abstract Since its discovery CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeat) has been widely used in gene editing. The associated protein- Cas9 has abled this coupled system to make very specific DNA modification. Earlier discovered gene editing methods like knock-in methods showed low efficiency in specific targeting. Here we review the principles and recent advancements … Read more

How CRISPR/Cas9 is used for development in therapeutic for cancer

Cancer being one of the major causes of disease associated mortality along with being increased with time worldwide. The main pillar in developing therapeutic and medicine for cancer involves improved understanding of tumor biology. The studying of tumor biology led to understanding of the key proteins of oncogenic signalling pathway. This led to development of … Read more

CRISPR technology – possibilities, implications and risks

A relatively new technology known as CRISPRCas9 has the capability to create global impact upon the way scientists investigate and medical professionals treat certain diseases in the future. ‘CRISPR’ which stands for ‘clusters of regularly interspaced short palindromic repeats’, palindromic meaning that it reads the same both forwards and backwards is a special kind of … Read more

Molecular approaches to the diagnosis or treatments of a genetic disorder

Genetic coding of human cells is made up of Deoxyribonucleic acid (DNA). The characteristics of the human cellular system specifies the building block of proteins and molecules of ribonucleic acid (RNA). Nucleic acids are made up of polymers of long chains of monomers repeating themselves over and over. They may be double stranded or single … Read more

Ethical concerns about CRISPR

Humans have been engineering life since early prehistory. Through selective breeding, we have been exploiting beneficial traits in plants and animals for millennia (Darwin 1859, 61). Yet, selective breeding is a very slow and often unpredictable process. But as soon as the code of life, DNA, was discovered, things started to change. In the early … Read more