The Role of N-Cadherin in Malignant Melanoma: How It Affects Cell Motility and MMP Activity
Malignant melanoma is the most aggressive and therapy resistant type of cancer leading to malignant transformation of pigment skin cells, melanocytes. Progression and metastasis of melanoma tumours strongly correlates with dynamic regulation of cadherin expression. In many cases, cell motility is physically and biochemically stimulated by N-cadherin – mediated cell interactions and signalling pathways. Our … Read more