Sickle cell disease
Sickle cell disease is an inherited blood disease which arises because of defect in beta-globin gene, a protein component of hemoglobin. Gamma-globin genes encode the fetal globin chain which can substitute the mutated or defective beta-globin chain, but expression of gamma-globin gene is inactivated prior to birth (1). Reactivation of normal fetal globin genes and … Read more