ENHANCEMENT OF AQUEOUS SOLUBILITY OF ETOPOSIDE USING SOLID DISPERSION TECHNIQUE

CHAPTER -1 INTRODUCTION SMRITI COLLEGE OF PHARMACEUTICAL EDUCATION, INDORE PAGE 1 ENHANCEMENT OF AQUEOUS SOLUBILITY OF ETOPOSIDE USING SOLID DISPERSION TECHNIQUE Introduction – Poorly water soluble drugs are concerned with the slow drug absorption and have insufficient and variable bioavailability, 40% of a raw drug had been identified which are poorly water soluble. Founded on … Read more

Yield response to salinity and sodicity of irrigation water

PRELIMINARY GUIDELINE FOR YIELD RESPONSE TO SALINITY AND SODICITY OF IRRIGATION WATER UNDER NORTH NILE DELTA CONDITIONS ABSTRACT Preliminary Guideline of tolerance of soybean, canola, sunflower, cotton and sugar beet crops to salinity and sodicity of irrigation water were introduced through long term lysimeter experiments in sand culture under North Delta climatic conditions. Linear equation … Read more

Cutaneous melanoma

Cutaneous melanoma represents the fastest growing cancer by incidence in the United States. Our group set out to contribute to the search for better biomarkers in order to improve current diagnostic capabilities towards melanoma. Our groups in silico investigations began by identifying genes with the strongest co-expression to tyrosinase (TYR), a well-known marker in melanoma … Read more

Evolutionary theory

It is common knowledge that Darwin s Theory of Evolution is one of the most influential scientific theories of modern day. This scientific theory takes the form of an ideology in which it is rarely contested and largely taken for granted. Placing unquestioning faith in the Theory of Evolution is counter-intuitive of science itself, as … Read more

Chemical reactions

The goal of the lab was to show learn about chemical reactions. It showed the different types of chemical reactions (synthesis, decomposition, single replacement, double replacement, and combustion.) In the lab different elements and compounds were combined to observe chemical reactions and see what they could look like. The reactions also showed whether or not … Read more

How Experimenter Attitude May Affect Participant Performance

Adair, J. G., Demand characteristics or conformity: Suspiciousness of deception and experimenter bias in conformity research. Canadian Journal of Behavioral Science/Revue Canadian Sciences of Comportment, 4(3). 238-248. The objective was to examine if subjects are suspicious of deception, and the effect of this suspiciousness on his response to the conformity pressure. The present observation of … Read more

Antibiotic Resistant Bacteria and Resistance Genes

Effect of Composting on the Prevalence of Antibiotic Resistant Bacteria and Resistance Genes in Cattle Manure Introduction Antibiotic resistance is a cause for growing concern because of its increasing prevalence, costs to the economy and disastrous impacts on human health [1]. The transmittance of antibiotic resistance genes has enabled livestock to be a source of … Read more

US28 HCMV (Human Cyto-Megalo Virus) encoded vGPCR

US28 is one of four HCMV (Human Cyto-Megalo Virus) encoded vGPCRs that has been extensively studied over the years. It exhibits high constitutive activity and posseses the ability to bind ligands from two separate chemokine classes. The subsequent distinct signalling pathways are initated upon G-protein activation and interestingly, dependent on the type (or the absence) … Read more

Drug administration

The administration of active pharmaceutical ingredient via oral route is the most convenient and acceptable route of drug administration (Christiansen et al., 2014). However, the bioavailability of drugs via this route is the major issue for a formulator. In addition, the 40% of new APIs that reaches to a formulator are with poor water solubility, … Read more

Pharmacokinetics of HIV-integrase inhibitors

Pharmacokinetics of HIV-integrase inhibitors is influenced by physiological changes occurring during pregnancy. (1) Very little information is available regarding altered pharmacokinetics in pregnant and required dosage adjustments of these drugs. (2) Especially for new developed drugs, such as HIV-integrase inhibitors, a knowledge gap exists on the influence of pregnancy-related mechanisms on altered maternal pharmacokinetics, drug … Read more

Power and privilege in psychedelic science: A call for cultural humility

Psychedelic science is gaining momentum and increased recognition in the United States. Promises of psychedelic science include the opportunity to transform consciousness itself, to creatively generate new solutions to old problems, to elicit deep healing through self-reflection. Several private organizations and donors are funding this psychedelic renaissance, with kindness and generosity fueling their interest and … Read more

Chromosome number

Chromosome number and the drivers of its variation were examined in 6 major angiosperm clades of Italian endemic vascular plants. As chromosome number can be employed as a surrogate of recombination rate, we investigated whether low chromosome numbers are favoured in individuals living in unstable environments ensuring immediate fitness.   We tested our hypothesis by … Read more

Audit sampling

Audit sampling used in every audit engagement and the practice regarding audit sampling around the world has an international structure which is defined by the International Standards on Auditing(ISA). The topic which is described in this report is based on audit sampling and the practice of audit sampling in audit procedures. There are specific guidelines … Read more

Fruit fertilization

Fruit is a structure which arises from an ovary or fusion of several ovaries after fertilization and may or may not carry associated floral parts. Fruit formation is an evolutionary mechanism designed to support and dispersal of seed by various agencies.With few exceptions e.g. banana, it is necessary for the flowers to be fertilized to … Read more